https://www.biomedicalengineeringatutsw.org/biomaterials-mechanics-tissue-engineering daily 0.75 2023-08-29 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/86f275d0-2b36-4e15-bd97-8e7330f09570/ATAC+seq.png Biomaterials, Mechanics, & Tissue Engineering Utilizing genetically modified mice with temporally activated fluorescent proteins within specific cell types, our laboratory can uncover cell populations (red) that contribute to the formation of diseases such as heterotopic ossification https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/352d5b73-3adc-4452-a65f-b998d4770617/CellWithinCollagen.png Biomaterials, Mechanics, & Tissue Engineering A 3-D model of ocular wound healing reveals how cells (green) compact and align extracellular collagen (red) through the generation of mechanical forces https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/e55d654d-b00d-4c51-8887-1602f0fa15ec/FEM_Fibroblast+UPDATED.png Biomaterials, Mechanics, & Tissue Engineering Combining live cell imaging of fluorescently labeled cells with finite element modeling leads to novel insights into sub-cellular patterns of force generation, which can improve our understanding of fundamental processes such as wound healing and embryonic development https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/9f6f805c-9bc5-415e-ba02-12cf5d05270c/Phalloidin_SHG_DTAF_PNG.png Biomaterials, Mechanics, & Tissue Engineering Combinations of advanced techniques such as multiphoton fluorescence and second harmonic generation imaging are used to study tissue remodeling and regeneration. Understanding these processes is critical to developing new therapies for treating blindness due to corneal scarring https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/176ff86c-a962-4b5d-b3c3-b19a1c8de46c/HO_Image.jpg Biomaterials, Mechanics, & Tissue Engineering Scanning confocal microscopy imaging allows for whole-section, high-resolution imaging to elucidate the spatial expression patterns of proteins of interest (purple). https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/c6eab00c-9668-4ab6-abbf-59c61d21184c/Picture1+copyPNG.png Biomaterials, Mechanics, & Tissue Engineering Interactions between cells (green) and the extracellular matrix (red) following laser refractive surgery in the cornea provides insights into how healing and remodeling are regulated https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/0bee519b-f977-414f-a1fb-04e71c8e303f/intuitive+prosthetic+interface.png Biomaterials, Mechanics, & Tissue Engineering Building intuitive prosthetic interface for seamless motor coordination in amputee patients https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/e2a116a2-5f88-4ff8-8e81-e0a07003f4b2/human+HO_updated.jpeg Biomaterials, Mechanics, & Tissue Engineering CT scan of human Heterotopic ossification. This is a disorder where the formation of ectopic bone happens in soft tissues of the musculoskeletal system due to an activating point mutation in ACVR1 gene, high energy traumatic injuries such as burn or blast wounds, invasive orthopedic cases, or severe brain and spinal cord injuries https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/9fee3461-9c08-4740-a814-443a7c639cda/Mouse_HO_updated.png Biomaterials, Mechanics, & Tissue Engineering Mouse hindlimb uCT: Levi Lab has generated a mouse model that reliably and reproducibly replicates the formation of human traumatic heterotopic ossification allowing for in vivo studies of the debilitating disease https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/91e964b1-5921-4a22-8bb5-dde64f860971/Mahendroo_BME+image+only.png Biomaterials, Mechanics, & Tissue Engineering The Mahendroo Lab uses the mouse as a model system to study term and preterm birth. The focus is to define the molecular steps that transition the cervix from a closed rigid structure to one that opens for a term birth. https://www.biomedicalengineeringatutsw.org/biomedical-molecular-imaging daily 0.75 2024-10-29 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/5529e81c-ee6d-4ad7-beee-91ea385538ae/Imaging+modality+-+optical.png Biomedical & Molecular Imaging Optical Imaging https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/71123fc8-1a2a-4801-9d26-87016ed01445/Preclinical.jpg Biomedical & Molecular Imaging https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/7801996d-297b-4fd1-be22-75719b7a332a/Image+4.png Biomedical & Molecular Imaging https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/f66fa9f3-db0e-4dd5-961e-0f50f38f00f4/Image+8.png Biomedical & Molecular Imaging https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/0a9c34e9-b803-43c9-a0f3-b107b013add4/Clinical.png Biomedical & Molecular Imaging https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/484951e0-cf2a-40ba-a66f-940134a96785/Data+Science.png Biomedical & Molecular Imaging https://www.biomedicalengineeringatutsw.org/computational-biology daily 0.75 2023-08-29 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/0bcb4a25-364d-4b7f-926b-b78838a1c5bf/1.png Computational Biology Students use GPU-compatible programming on cryogenic electron microscopy to determine the structure of macromolecular assemblies like the multienzyme Aro1 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/11aa3691-4c9c-4957-baf4-8e92341f232c/2.gif Computational Biology Computational Biology students collaborate with cancer cell biologists to model the relation between cell form and oncogenic signals by using and advancing methods of computer vision, computer graphics, and machine learning https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/c61bbac4-d781-453f-9705-df9d12addb33/3.png Computational Biology Students learn to combine molecular simulation with interpretable deep learning to discover principles of macromolecular self-organization. The goal is to accurately predict cryptic allosteric pathways to design unnatural protein sequences for novel functionality https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/88ea92e1-9bc9-4fcd-ad6d-2b10a71964ea/4.png Computational Biology Our students test and refine models of gene regulation in bacteria with thousands of high-throughput cell growth rate measurements in an upscaled turbidostat https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/cedd24d0-9de5-4e7b-8a9f-6abbbaf38b95/5.png Computational Biology Students develop innovative genomic approaches to model how genes and regulators influence individual cell states in development, disease, and regenerative medicine. https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/16c2221f-f1b8-47a9-a290-b0b6d9f1cefa/6.png Computational Biology Our students contribute to the deep learning sequence modeling framework, Sei, that maps the global regulatory landscape of genomic sequences and predicts the effects of regulatory mutations that cause human diseases. https://www.biomedicalengineeringatutsw.org/medical-physics daily 0.75 2023-08-29 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/59a5d4b4-295d-49ad-a9a3-a715650233c1/PET+imaging.png Medical Physics Phantom PET imaging and small animal cardiac and tumor PET imaging https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/4c6ca0b5-f091-4b5a-9f50-91be5dbd15d8/DVF.png Medical Physics Solving lung motion using different methods: (left) Demons algorithm; (middle) 2D-3D registration; and (right) Biomechanical modeling-guided registration https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/f9b40969-8275-42a2-a9c6-782a84ab22a3/PET-related+instrumentation.png Medical Physics Integrated PET/CT/RT for preclinical radiation research https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/4ec5bc4a-92ea-434f-a23a-62409415fa17/Radiotherapy+Dose+Prediction.png Medical Physics Comparison between the gold-standard human radiotherapy plan (top), the predicted plan from a general AI model (middle), and the predicted plan from a dedicated AI model (bottom) https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/148c654d-2149-4e9f-8865-364797df7c92/PET+imaging+for+Proton.png Medical Physics PET imaging for improving proton therapy https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/77254967-c344-45b8-b84a-94d641f0aaff/QBLT_guided+GBM+irradiation.png Medical Physics Quantitative bioluminescence tomography (QBLT) for pre-clinical radiation research https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/be6b664d-a235-4303-864f-02026822fdca/Image+Segmentation.png Medical Physics Uncertainty Estimation: Visualization of the clinical tumor contours (red) and the AI predicted mean tumor contours (blue) with 95% confidence bounds (yellow) https://www.biomedicalengineeringatutsw.org/molecular-translational-nanomedicine daily 0.75 2023-09-07 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/786ab68e-0510-40c0-9498-fb45be84777a/dataImage3.png Molecular & Translational Nanomedicine https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/f3138dfd-805b-48b4-a600-f92288274169/image+for+background+ext+site.emf.jpg Molecular & Translational Nanomedicine https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/38dc7db7-b54e-49cb-a391-bad65df37f00/nanotheranostics.png Molecular & Translational Nanomedicine https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/1252fcf9-c0dc-48e8-b430-a7697ed78a6a/kidney+brain+mets.png Molecular & Translational Nanomedicine https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/09763685-4704-46e6-930b-7bb13382962d/mrnadelivery.png Molecular & Translational Nanomedicine https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/aa2bd6fd-0a41-4282-ad80-9a207dc317f5/image+guided+drug+delivery.png Molecular & Translational Nanomedicine image guided drug delivery https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/b87e2cc7-390c-4172-9c0f-3ed8b9e0223b/spect-ct.png Molecular & Translational Nanomedicine SPECT/CT images of glutathione-coated gold nanoparticles in mice. a) 10 min; b) 1 h; 3) 4 h; and 4) 24 h post-injection Angew Chem Int Ed 2012, 51(40):10118-22 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/9ac94766-78ec-4cf1-bf74-af242b5f5fff/image+guided+drug+delivery.png Molecular & Translational Nanomedicine Axial MRI and APTw images show molecular changes in rat liver tumor (arrow) after locoregional injection of LDL-DHA nanoparticles. https://www.biomedicalengineeringatutsw.org/about-us daily 0.75 2025-04-25 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/15ed5f3a-7ecd-43bd-a6ea-bf7f07e02ff9/sam.JPG About Us - Samuel Achilefu’s message Professor Chair, Department of Biomedical Engineering Welcome to the Department of Biomedical Engineering at UT Southwestern, where creativity and innovative problem-solving initiatives are cherished. We live in a new era of technological revolution grounded on solid engineering principles, requiring that we embrace the concept of empowering health and science through technological innovations. We can accomplish this goal by transforming ideas into technology-driven clinical and biological solutions to improve health and understanding. My primary job as Chair is to create an exciting and collaborative environment for researchers, teachers, and trainees. This will enable us to educate the next generation of creative biomedical engineers, conduct and coordinate innovative and transformative research, and catalyze clinical and commercial translation of research discoveries and products. The setting of our BME Department in a medical center renowned for its patient care, paradigm-shifting biological sciences, and state-of-the-art research centers and core facilities provides a unique opportunity for biomedical engineers and physical scientists to work closely with clinicians and biological scientists and develop multidisciplinary teams to solve pressing challenges in medicine and biology. We encourage students to participate in experiential learning as a way of providing insight into clinical challenges. This approach is designed to stimulate students’ engagement in the early stages of their training and serve as the engine for developing innovative engineering solutions to clinical problems. Finally, I believe that science, engineering, and medicine thrive when people of diverse races, cultures, and representations participate in every level of the academic endeavor and leadership. Accordingly, our Department invites you to help us make this world a better place for all through your engineering, medical, and scientific prowess. I am fully committed to ensuring that everyone is treated fairly and equitably. I look forward to working with you. https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/f1983a2a-1bc8-4d09-af7a-832ad76b4a32/IanCorbin.jpg About Us - Ian Corbin’s message Associate Professor Director, Biomedical Engineering Graduate Program Biomedical Engineering – the application of engineering principles and design concepts to medicine and biology – offers a range of opportunities to improve human health and well-being. Housed in one of the nation’s leading academic medical centers and coordinated with the UTSW Department of Biomedical Engineering, the UTSW BME graduate program is focused on translational research advances in the understanding, detection, and treatment of human disease. Our graduate program features over 100 faculty members with appointments in basic science, engineering, and clinical departments, providing a wide range of research opportunities for our PhD students. In addition to the UTSW Department of Biomedical Engineering, we have inter-institutional collaborations with UT Dallas and UT Arlington engineering schools, thus our students have access to a range of resources for education and research training. Students in the BME Program are directly involved in the development and application of cutting-edge biomedical technologies, novel experimental approaches, and advanced computational techniques. As part of their research training, UTSW students learn to think critically, develop testable hypotheses, and design experiments that lead to new scientific discoveries and advances in clinical care. Our flexible curriculum and emphasis on experiential research training allows students to use their creativity, think independently, communicate effectively, and work collaboratively to push the boundaries of engineering, science and medicine. Thus, our graduates are ideally positioned to become leaders in both academic and industry settings. Thank you for your interest in our program. https://www.biomedicalengineeringatutsw.org/curriculum daily 0.75 2024-07-30 https://www.biomedicalengineeringatutsw.org/faculty daily 0.75 2025-04-25 https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/1658930957857-JNC4TJ1OU9WW8O9PP1FD/sam.JPG Faculty https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/1658931455818-SETHGZRGEF5XHSI3BRI9/yasin+dhaher.jpg Faculty https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/1658931650484-IURATIBMIR2QQQQL13IV/anke+henning.jpg Faculty https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/1660139175189-7S3CC3V88RFJJ4QE08LQ/thomas+carroll.jpg Faculty https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/1660139385029-LO29W7PM5T9CXQMR4P40/jonathan+cheng.jpg Faculty https://images.squarespace-cdn.com/content/v1/62bf062ecb4ed14317216d07/1660139507146-8GDSLSTM7DYOCKXK77TB/connie+hsia.jpg Faculty 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